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Audiogenic Seizures and Their Importance in Experimental Behavioral Studies: A Review

Ipek Komsuoglu Celikyurt, Esra Isık, Cem Onur Erdolu

Department of Pharmacology, Kocaeli University, Medical School, Kocaeli, Turkey

Med Sci Rev 2016; 3:110-118

DOI: 10.12659/MSRev.899608

Available online:

Published: 2016-09-06

ABSTRACT: The aim of this review is to explain and detail the role of audiogenic seizures (ASs) in neurobiological events occurring in the central nervous system (CNS) and their importance in experimental models in light of the current literature. Audiogenic seizures are a model of generalized tonic-clonic seizures, which are brainstem-generated. The rodent audiogenic seizure is a biological and genetic phenomenon. In this review, general features of audiogenic seizures in different rat and mouse strains are discussed, and we try to explain the neurotransmitter systems that are involved in audiogenic seizures and brain structures involved in the development of audiogenic seizures. We also address audiogenic seizure behavior and the relationship between neural plasticity and audiogenic kindling, as well as explaining audiogenic kindling, experimental studies in different drug groups, and the genetics involved.

Keywords: Epilepsy, Reflex, Models, Animal, Neuropharmacology