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Calorie Restriction and Epilepsy

Zheng Xiao, Liwei Tang

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland)

Med Sci Rev 2015; 2:150-155

DOI: 10.12659/MSRev.896553

Available online:

Published: 2015-11-23

ABSTRACT: Dietary restriction has been proposed as a method for extending lifespan. It can reduce oxidative stress damage, improve resistance, slow the aging process, and delay the development of age-related diseases in a variety of species. However, the mechanism by which this occurs remains unclear. Dietary restriction has been proven effective in epilepsy animal models in recent studies. A method called the ketogenic diet appeared to control epilepsy in clinical practice, but the emergence of anti-epileptic drugs slowed the development of diet therapy. Up to 20–40% of epilepsy patients ultimately become resistant to currently available anti-epileptic drugs. Once again, diet therapy is becoming a choice for treatment of epilepsy. This review discusses the history, animal research, and the mechanism of calorie restriction.

Keywords: Caloric Restriction, Diet Therapy, Epilepsy, Seizures