Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective therapeutic approach to obtain better glycemic control in type-2 diabetes mellitus patients. Various preclinical and clinical studies demonstrated the efficacy in cardiovascular benefits beside tight glycemic control. In September 2014 the Food and Drug Administration (FDA) approved the GLP-1 RA, Dulaglutide, for the treatment of type-2 diabetes mellitus. The series of AWARD (Assessment of Weekly Administration of LY2189265 in Diabetes) studies compared Dulaglutide with other anti-diabetic agents, with promising results, including weight reduction and controlled systolic blood pressure (BP). The safety panel of Dulaglutide demonstrated a tolerable adverse effect profile, mainly gastrointestinal.

Keywords: Awards and Prizes, Diabetes Mellitus, Type 2, Glucagon-Like Peptide 1, Incretins